An international, multi-disciplinary, peer-reviewed publication targeted to scientists and clinicians interested in systemic sclerosis, scleroderma, and other related autoimmune and fibrotic diseases. Systemic sclerosis (systemic scleroderma) is a chronic connective tissue disease of unknown etiology that causes widespread microvascular …
Two categories of scleroderma are known: systemic sclerosis, characterized by cutaneous sclerosis and visceral involvement, and localized scleroderma or morphea which classically presents benign and self-limited evolution and is …

Systemic sclerosis, also called scleroderma, is an immune-mediated rheumatic disease that is characterised by fibrosis of the skin and internal organs and vasculopathy. To the Editor: In their review article on scleroderma, Gabrielli et al. Scleroderma is a rare connective tissue disease that is manifested by cutaneous sclerosis and variable systemic involvement. The official independent journal of the World Scleroderma Foundation and EUSTAR. It is a long-term, progressive disease. About this journal. Scleroderma refers to a range of disorders in which the skin and connective tissues tighten and harden. It is a rare multisystem autoimmune disease of the connective tissue, distinguished by prominent fibrosis and vasculopathy of the skin and internal organs. It … Of all the rheumatological diseases, systemic sclerosis (scleroderma) has the highest case-specific mortality and substantial non-lethal complications. Although systemic sclerosis is uncommon, it has a high morbidity and mortality. This means it gradually gets worse.